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The effects of the analysis strategy on the correlation between the NIRS reperfusion measures and the FMD response. Soares RN, de Oliveira GV, Alvares TS, Murias JM. Impact of microencapsulated watermelon (Citrullus lanatus) and beetroot (Beta vulgaris L) on storage stability of l-citrulline and dietary nitrate. Volino-Souza M, de Oliveira GV, do Couto Vellozo O, Conte-Junior CA, da Silveira, Alvares T. Argininosuccinate synthase: at the center of arginine metabolism. Therapeutic use of citrulline in cardiovascular disease. Romero MJ, Platt DH, Caldwell RB, Caldwell RW. The role of nitric oxide on endothelial function. Tousoulis D, Kampoli AM, Tentolouris C, Papageorgiou N, Stefanadis C. ConclusionĪ single dose of microencapsulated watermelon rind containing 4 g of L-citrulline seems adequate to improve FMD response, but not StO 2 parameters in healthy adults. Absolute plasma L-citrulline and relative change from baseline in plasma L-arginine increased 60 min after MWR ingestion. The FMD improved 60 min after MWR without changes in StO 2 parameters. Before and 30, 60, 90, and 120 min after ingestion, StO 2 parameters were assessed, whereas FMD and plasma amino acids were analyzed 60 and 120 min after ingestion. Subject/MethodsĮleven participants ingested 30 g of MWR (containing 4 g of L-citrulline) and a placebo. Plasma L-arginine and L-citrulline were also evaluated. Given that Lcitrulline is involved in nitric oxide (NO) synthesis, a crucial molecule that regulates vascular function, this study aimed to evaluate the effect of microencapsulated watermelon rind (MWR) on endothelial function and tissue oxygen saturation (StO 2) assessed by flow-mediated dilation (FMD) and near-infrared spectroscopy, respectively. Watermelon rind (usually discarded by consumers) presents a high L-citrulline content.

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